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Ligand-gated chloride channels are receptors for biogenic amines in C. elegans.

Science (New York, N.Y.) | Jul 3, 2009

http://www.ncbi.nlm.nih.gov/pubmed/19574391

Biogenic amines such as serotonin and dopamine are intercellular signaling molecules that function widely as neurotransmitters and neuromodulators. We have identified in the nematode Caenorhabditis elegans three ligand-gated chloride channels that are receptors for biogenic amines: LGC-53 is a high-affinity dopamine receptor, LGC-55 is a high-affinity tyramine receptor, and LGC-40 is a low-affinity serotonin receptor that is also gated by choline and acetylcholine. lgc-55 mutants are defective in a behavior that requires endogenous tyramine, which indicates that this ionotropic tyramine receptor functions in tyramine signaling in vivo. Our studies suggest that direct activation of membrane chloride conductances is a general mechanism of action for biogenic amines in the modulation of C. elegans behavior.

Pubmed ID: 19574391 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Biogenic Amines | Caenorhabditis elegans | Caenorhabditis elegans Proteins | Chloride Channels | Dopamine | Genes, Helminth | Ligands | Membrane Potentials | Molecular Sequence Data | Mutant Proteins | Oocytes | Patch-Clamp Techniques | Receptors, Biogenic Amine | Serotonin | Tyramine | Xenopus

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Associated grants

  • Agency: NIGMS NIH HHS, Id: GM24663
  • Agency: NIGMS NIH HHS, Id: R01 GM024663
  • Agency: NIGMS NIH HHS, Id: R01 GM024663-32A1
  • Agency: Howard Hughes Medical Institute, Id:

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