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Ligand-gated chloride channels are receptors for biogenic amines in C. elegans.

Science (New York, N.Y.) | Jul 3, 2009

Biogenic amines such as serotonin and dopamine are intercellular signaling molecules that function widely as neurotransmitters and neuromodulators. We have identified in the nematode Caenorhabditis elegans three ligand-gated chloride channels that are receptors for biogenic amines: LGC-53 is a high-affinity dopamine receptor, LGC-55 is a high-affinity tyramine receptor, and LGC-40 is a low-affinity serotonin receptor that is also gated by choline and acetylcholine. lgc-55 mutants are defective in a behavior that requires endogenous tyramine, which indicates that this ionotropic tyramine receptor functions in tyramine signaling in vivo. Our studies suggest that direct activation of membrane chloride conductances is a general mechanism of action for biogenic amines in the modulation of C. elegans behavior.

Pubmed ID: 19574391 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Biogenic Amines | Caenorhabditis elegans | Caenorhabditis elegans Proteins | Chloride Channels | Dopamine | Genes, Helminth | Ligands | Membrane Potentials | Molecular Sequence Data | Mutant Proteins | Oocytes | Patch-Clamp Techniques | Receptors, Biogenic Amine | Serotonin | Tyramine | Xenopus

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Associated grants

  • Agency: NIGMS NIH HHS, Id: R01 GM024663
  • Agency: NIGMS NIH HHS, Id: R37 GM024663
  • Agency: Howard Hughes Medical Institute, Id: GM24663
  • Agency: NIGMS NIH HHS, Id: R01 GM024663-32A1
  • Agency: NIGMS NIH HHS, Id:

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