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Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia.

PloS one | 2009

Hypoxia and pressure-overload induce heme oxygenase-1 (HO-1) in cardiomyocytes and vascular smooth muscle cells (VSMCs). HO-1(-/-) mice exposed to chronic hypoxia develop pulmonary arterial hypertension (PAH) with exaggerated right ventricular (RV) injury consisting of dilation, fibrosis, and mural thrombi. Our objective was to identify the HO-1 product(s) mediating RV protection from hypoxic injury in HO-1(-/-) mice.

Pubmed ID: 19543386 RIS Download

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Associated grants

  • Agency: NHLBI NIH HHS, United States
    Id: K08 HL077344
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL055454
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL085446
  • Agency: NHLBI NIH HHS, United States
    Id: HL085446

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WI (tool)

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