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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.

Nature neuroscience | Jul 25, 2009

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics.

Pubmed ID: 19503083 RIS Download

Mesh terms: Age Factors | Animals | Antiparkinson Agents | Apomorphine | Brain | Chromosomes, Artificial, Bacterial | Disease Models, Animal | Dopamine | Dopamine Uptake Inhibitors | Gene Transfer Techniques | Humans | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Levodopa | Mice | Mice, Transgenic | Movement Disorders | Mutation, Missense | Neurons | Nomifensine | Parkinson Disease | Protein-Serine-Threonine Kinases

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Associated grants

  • Agency: NINDS NIH HHS, Id: P50 NS038370
  • Agency: NINDS NIH HHS, Id: P50 NS038370-09
  • Agency: NINDS NIH HHS, Id: R01 NS026836
  • Agency: NINDS NIH HHS, Id: P50 NS038370-090003
  • Agency: NINDS NIH HHS, Id: R01 NS026836-18

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