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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics.

Pubmed ID: 19503083


  • Li Y
  • Liu W
  • Oo TF
  • Wang L
  • Tang Y
  • Jackson-Lewis V
  • Zhou C
  • Geghman K
  • Bogdanov M
  • Przedborski S
  • Beal MF
  • Burke RE
  • Li C


Nature neuroscience

Publication Data

July 25, 2009

Associated Grants

  • Agency: NINDS NIH HHS, Id: P50 NS038370
  • Agency: NINDS NIH HHS, Id: P50 NS038370-09
  • Agency: NINDS NIH HHS, Id: P50 NS038370-090003
  • Agency: NINDS NIH HHS, Id: R01 NS026836
  • Agency: NINDS NIH HHS, Id: R01 NS026836-18

Mesh Terms

  • Age Factors
  • Animals
  • Antiparkinson Agents
  • Apomorphine
  • Brain
  • Chromosomes, Artificial, Bacterial
  • Disease Models, Animal
  • Dopamine
  • Dopamine Uptake Inhibitors
  • Gene Transfer Techniques
  • Humans
  • Levodopa
  • Mice
  • Mice, Transgenic
  • Movement Disorders
  • Mutation, Missense
  • Neurons
  • Nomifensine
  • Parkinson Disease
  • Protein-Serine-Threonine Kinases