• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics.

Pubmed ID: 19503083

Authors

  • Li Y
  • Liu W
  • Oo TF
  • Wang L
  • Tang Y
  • Jackson-Lewis V
  • Zhou C
  • Geghman K
  • Bogdanov M
  • Przedborski S
  • Beal MF
  • Burke RE
  • Li C

Journal

Nature neuroscience

Publication Data

July 25, 2009

Associated Grants

  • Agency: NINDS NIH HHS, Id: P50 NS038370
  • Agency: NINDS NIH HHS, Id: P50 NS038370-09
  • Agency: NINDS NIH HHS, Id: P50 NS038370-090003
  • Agency: NINDS NIH HHS, Id: R01 NS026836
  • Agency: NINDS NIH HHS, Id: R01 NS026836-18

Mesh Terms

  • Age Factors
  • Animals
  • Antiparkinson Agents
  • Apomorphine
  • Brain
  • Chromosomes, Artificial, Bacterial
  • Disease Models, Animal
  • Dopamine
  • Dopamine Uptake Inhibitors
  • Gene Transfer Techniques
  • Humans
  • Levodopa
  • Mice
  • Mice, Transgenic
  • Movement Disorders
  • Mutation, Missense
  • Neurons
  • Nomifensine
  • Parkinson Disease
  • Protein-Serine-Threonine Kinases