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GOAT links dietary lipids with the endocrine control of energy balance.

Nature medicine | Jul 8, 2009

http://www.ncbi.nlm.nih.gov/pubmed/19503064

Central nervous system nutrient sensing and afferent endocrine signaling have been established as parallel systems communicating metabolic status and energy availability in vertebrates. The only afferent endocrine signal known to require modification with a fatty acid side chain is the orexigenic hormone ghrelin. We find that the ghrelin O-acyl transferase (GOAT), which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylation substrates and links ingested lipids to energy expenditure and body fat mass. These data implicate the ghrelin-GOAT system as a signaling pathway that alerts the central nervous system to the presence of dietary calories, rather than to their absence as is commonly accepted.

Pubmed ID: 19503064 RIS Download

Mesh terms: Acyltransferases | Animals | Dietary Fats | Energy Metabolism | Ghrelin | Mice | Mice, Inbred C57BL | Mice, Knockout | RNA, Messenger | Signal Transduction | Triglycerides

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Associated grants

  • Agency: NIDDK NIH HHS, Id: P01 DK056863
  • Agency: NIDDK NIH HHS, Id: P01 DK056863-099002
  • Agency: NIDDK NIH HHS, Id: R01 DK069987
  • Agency: NIDDK NIH HHS, Id: R01 DK069987-04
  • Agency: NIDDK NIH HHS, Id: R01 DK077975
  • Agency: NIDDK NIH HHS, Id: R01 DK077975-01A2
  • Agency: NIDDK NIH HHS, Id: R01-DK069987

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