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GOAT links dietary lipids with the endocrine control of energy balance.

Central nervous system nutrient sensing and afferent endocrine signaling have been established as parallel systems communicating metabolic status and energy availability in vertebrates. The only afferent endocrine signal known to require modification with a fatty acid side chain is the orexigenic hormone ghrelin. We find that the ghrelin O-acyl transferase (GOAT), which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylation substrates and links ingested lipids to energy expenditure and body fat mass. These data implicate the ghrelin-GOAT system as a signaling pathway that alerts the central nervous system to the presence of dietary calories, rather than to their absence as is commonly accepted.

Pubmed ID: 19503064


  • Kirchner H
  • Gutierrez JA
  • Solenberg PJ
  • Pfluger PT
  • Czyzyk TA
  • Willency JA
  • Schürmann A
  • Joost HG
  • Jandacek RJ
  • Hale JE
  • Heiman ML
  • Tschöp MH


Nature medicine

Publication Data

July 8, 2009

Associated Grants

  • Agency: NIDDK NIH HHS, Id: P01 DK056863
  • Agency: NIDDK NIH HHS, Id: P01 DK056863-099002
  • Agency: NIDDK NIH HHS, Id: R01 DK069987
  • Agency: NIDDK NIH HHS, Id: R01 DK069987-04
  • Agency: NIDDK NIH HHS, Id: R01 DK077975
  • Agency: NIDDK NIH HHS, Id: R01 DK077975-01A2
  • Agency: NIDDK NIH HHS, Id: R01-DK069987

Mesh Terms

  • Acyltransferases
  • Animals
  • Dietary Fats
  • Energy Metabolism
  • Ghrelin
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • RNA, Messenger
  • Signal Transduction
  • Triglycerides