Literature search services are currently unavailable. During our hosting provider's UPS upgrade we experienced a hardware failure and are currently working to resolve the issue.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model.

Abnormal N-methyl-d-aspartate receptor (NMDAR) function has been implicated in the pathophysiology of schizophrenia. d-serine is an important NMDAR modulator, and to elucidate the role of the d-serine synthesis enzyme serine racemase (Srr) in schizophrenia, we identified and characterized mice with an ENU-induced mutation that results in a complete loss of Srr activity and dramatically reduced d-serine levels. Mutant mice displayed behaviors relevant to schizophrenia, including impairments in prepulse inhibition, sociability and spatial discrimination. Behavioral deficits were exacerbated by an NMDAR antagonist and ameliorated by d-serine or the atypical antipsychotic clozapine. Expression profiling revealed that the Srr mutation influenced several genes that have been linked to schizophrenia and cognitive ability. Transcript levels altered by the Srr mutation were also normalized by d-serine or clozapine treatment. Furthermore, analysis of SRR genetic variants in humans identified a robust association with schizophrenia. This study demonstrates that aberrant Srr function and diminished d-serine may contribute to schizophrenia pathogenesis.

Pubmed ID: 19483194


  • Labrie V
  • Fukumura R
  • Rastogi A
  • Fick LJ
  • Wang W
  • Boutros PC
  • Kennedy JL
  • Semeralul MO
  • Lee FH
  • Baker GB
  • Belsham DD
  • Barger SW
  • Gondo Y
  • Wong AH
  • Roder JC


Human molecular genetics

Publication Data

September 1, 2009

Associated Grants

  • Agency: NIA NIH HHS, Id: P01AG12411

Mesh Terms

  • Animals
  • Case-Control Studies
  • Disease Models, Animal
  • Disease Susceptibility
  • Female
  • Humans
  • Male
  • Mice
  • Mice, Inbred Strains
  • Mutation
  • Pedigree
  • Racemases and Epimerases
  • Schizophrenia
  • Serine