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Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.

Lysophosphatidic acid (LPA) acts through high-affinity G protein-coupled receptors to mediate a plethora of physiological and pathological activities associated with tumorigenesis. LPA receptors and autotaxin (ATX/LysoPLD), the primary enzyme producing LPA, are aberrantly expressed in multiple cancer lineages. However, the role of ATX and LPA receptors in the initiation and progression of breast cancer has not been evaluated. We demonstrate that expression of ATX or each edg family LPA receptor in mammary epithelium of transgenic mice is sufficient to induce a high frequency of late-onset, estrogen receptor (ER)-positive, invasive, and metastatic mammary cancer. Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer.

Pubmed ID: 19477432


  • Liu S
  • Umezu-Goto M
  • Murph M
  • Lu Y
  • Liu W
  • Zhang F
  • Yu S
  • Stephens LC
  • Cui X
  • Murrow G
  • Coombes K
  • Muller W
  • Hung MC
  • Perou CM
  • Lee AV
  • Fang X
  • Mills GB


Cancer cell

Publication Data

June 2, 2009

Associated Grants

  • Agency: NCI NIH HHS, Id: CA099031
  • Agency: NCI NIH HHS, Id: CA64602
  • Agency: NCI NIH HHS, Id: CA82716
  • Agency: NCI NIH HHS, Id: P01 CA064602
  • Agency: NCI NIH HHS, Id: P01 CA099031
  • Agency: NCI NIH HHS, Id: P30 CA016672
  • Agency: NCI NIH HHS, Id: P30CA016672
  • Agency: NCI NIH HHS, Id: P50 CA098258
  • Agency: NCI NIH HHS, Id: R01 CA082716

Mesh Terms

  • Adenocarcinoma
  • Animals
  • Carcinoma, Adenosquamous
  • Cell Transformation, Neoplastic
  • Cloning, Molecular
  • Female
  • Humans
  • Lung Neoplasms
  • Lymphatic Metastasis
  • Male
  • Mammary Neoplasms, Experimental
  • Mice
  • Mice, Transgenic
  • Multienzyme Complexes
  • Neoplasm Invasiveness
  • Neoplasms, Hormone-Dependent
  • Phosphodiesterase I
  • Phosphoric Diester Hydrolases
  • Pyrophosphatases
  • Receptors, Estrogen
  • Receptors, Lysophosphatidic Acid
  • Signal Transduction