We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Proteasomal regulation of the hypoxic response modulates aging in C. elegans.

Science (New York, N.Y.) | May 29, 2009

The Caenorhabditis elegans von Hippel-Lindau tumor suppressor homolog VHL-1 is a cullin E3 ubiquitin ligase that negatively regulates the hypoxic response by promoting ubiquitination and degradation of the hypoxic response transcription factor HIF-1. Here, we report that loss of VHL-1 significantly increased life span and enhanced resistance to polyglutamine and beta-amyloid toxicity. Deletion of HIF-1 was epistatic to VHL-1, indicating that HIF-1 acts downstream of VHL-1 to modulate aging and proteotoxicity. VHL-1 and HIF-1 control longevity by a mechanism distinct from both dietary restriction and insulin-like signaling. These findings define VHL-1 and the hypoxic response as an alternative longevity and protein homeostasis pathway.

Pubmed ID: 19372390 RIS Download

Mesh terms: Aging | Amyloid beta-Peptides | Animals | Caenorhabditis elegans | Caenorhabditis elegans Proteins | Caloric Restriction | Cullin Proteins | Female | Fertility | Gene Expression Regulation | Homeostasis | Insulin | Longevity | Male | Models, Animal | Oxygen | Peptides | Proteasome Endopeptidase Complex | RNA Interference | Receptor, Insulin | Signal Transduction | Transcription Factors | Ubiquitination

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

Associated grants

  • Agency: NIA NIH HHS, Id: R01 AG031108
  • Agency: NIA NIH HHS, Id: R01 AG031108-01A1
  • Agency: NIA NIH HHS, Id: 1R01AG031108-01
  • Agency: NIA NIH HHS, Id: P30AG013280

WormBase (Data, Gene Expression)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.