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The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.

BMB reports | Mar 31, 2009

JARID1B (jumonji AT rich interactive domain 1B) is a large nuclear protein that is highly expressed in breast cancers and is proposed to function as a repressor of gene expression. In this paper, a phage display screen using the N-terminus of JARID1B as bait identified one of the JARID1B interacting proteins, namely PcG protein (Polycomb group) hPc2. We demonstrated that the C-terminal region, including the COOH box, was required for the interaction with the N-terminus of JARID1B. In a reporter assay system, co-expression of JARID1B with hPc2 significantly enhanced the transcriptional repression. These results support a role for hPc2 acting as a transcriptional co-repressor.

Pubmed ID: 19336002 RIS Download

Mesh terms: Cell Line, Tumor | DNA-Binding Proteins | Humans | Jumonji Domain-Containing Histone Demethylases | Ligases | Nuclear Proteins | Oxidoreductases, N-Demethylating | Peptide Library | Polycomb-Group Proteins | Protein Binding | Repressor Proteins | Transcription, Genetic | Ubiquitin-Protein Ligases

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