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The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.

JARID1B (jumonji AT rich interactive domain 1B) is a large nuclear protein that is highly expressed in breast cancers and is proposed to function as a repressor of gene expression. In this paper, a phage display screen using the N-terminus of JARID1B as bait identified one of the JARID1B interacting proteins, namely PcG protein (Polycomb group) hPc2. We demonstrated that the C-terminal region, including the COOH box, was required for the interaction with the N-terminus of JARID1B. In a reporter assay system, co-expression of JARID1B with hPc2 significantly enhanced the transcriptional repression. These results support a role for hPc2 acting as a transcriptional co-repressor.

Pubmed ID: 19336002


  • Zhou W
  • Chen H
  • Zhang L


BMB reports

Publication Data

March 31, 2009

Associated Grants


Mesh Terms

  • Cell Line, Tumor
  • DNA-Binding Proteins
  • Humans
  • Jumonji Domain-Containing Histone Demethylases
  • Nuclear Proteins
  • Oxidoreductases, N-Demethylating
  • Peptide Library
  • Polycomb-Group Proteins
  • Protein Binding
  • Repressor Proteins
  • Transcription, Genetic
  • Ubiquitin-Protein Ligases