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Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.

Nature genetics | May 28, 2009

A mutational analysis of the matrix metalloproteinase (MMP) gene family in human melanoma identified somatic mutations in 23% of melanomas. Five mutations in one of the most commonly mutated genes, MMP8, reduced MMP enzyme activity. Expression of wild-type but not mutant MMP8 in human melanoma cells inhibited growth on soft agar in vitro and tumor formation in vivo, suggesting that wild-type MMP-8 has the ability to inhibit melanoma progression.

Pubmed ID: 19330028 RIS Download

Mesh terms: Chromosomal Instability | Glaucoma | Glioma | Humans | Matrix Metalloproteinase 8 | Melanoma | Mutation

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Associated grants

  • Agency: Intramural NIH HHS, Id: Z01 HG200337-01
  • Agency: Intramural NIH HHS, Id: Z99 HG999999

Comparative Toxicogenomics Database (Data, Disease Annotation)

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