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Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.

A mutational analysis of the matrix metalloproteinase (MMP) gene family in human melanoma identified somatic mutations in 23% of melanomas. Five mutations in one of the most commonly mutated genes, MMP8, reduced MMP enzyme activity. Expression of wild-type but not mutant MMP8 in human melanoma cells inhibited growth on soft agar in vitro and tumor formation in vivo, suggesting that wild-type MMP-8 has the ability to inhibit melanoma progression.

Pubmed ID: 19330028

Authors

  • Palavalli LH
  • Prickett TD
  • Wunderlich JR
  • Wei X
  • Burrell AS
  • Porter-Gill P
  • Davis S
  • Wang C
  • Cronin JC
  • Agrawal NS
  • Lin JC
  • Westbroek W
  • Hoogstraten-Miller S
  • Molinolo AA
  • Fetsch P
  • Filie AC
  • O'Connell MP
  • Banister CE
  • Howard JD
  • Buckhaults P
  • Weeraratna AT
  • Brody LC
  • Rosenberg SA
  • Samuels Y

Journal

Nature genetics

Publication Data

May 28, 2009

Associated Grants

  • Agency: Intramural NIH HHS, Id: Z01 HG200337-01
  • Agency: Intramural NIH HHS, Id: Z99 HG999999

Mesh Terms

  • Chromosomal Instability
  • Glaucoma
  • Glioma
  • Humans
  • Matrix Metalloproteinase 8
  • Melanoma
  • Mutation