Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses.

Nature neuroscience | Apr 26, 2009

Sonic Hedgehog (Shh) has dual roles in vertebrate development, promoting progenitor cell proliferation and inducing tissue patterning. We found that the mitogenic and patterning functions of Shh can be uncoupled from one another. Using a genetic approach to selectively inhibit Shh-proteoglycan interactions in a mouse model, we found that binding of Shh to proteoglycans was required for proliferation of neural stem/precursor cells, but not for tissue patterning. Shh-proteoglycan interactions regulated both spatial and temporal features of Shh signaling. Proteoglycans localized Shh to specialized mitogenic niches and also acted at the single-cell level to regulate the duration of Shh signaling, thereby promoting a gene expression program that is important for cell division. Because activation of the Shh pathway is a feature of diverse human cancers, selective stimulation of proliferation by Shh-proteoglycan interactions may also figure prominently in neoplastic growth.

Pubmed ID: 19287388 RIS Download

Mesh terms: Animals | Animals, Newborn | Body Patterning | Bromodeoxyuridine | Cell Proliferation | Central Nervous System | Embryo, Mammalian | Fibrinolytic Agents | Gene Expression | Gene Expression Regulation, Developmental | Glycosylphosphatidylinositols | Hedgehog Proteins | Heparin | Histones | In Situ Nick-End Labeling | Kruppel-Like Transcription Factors | Mice | Mice, Transgenic | Mitosis | Mutation | Nerve Tissue Proteins | Protein Binding | Proteoglycans | Stem Cells

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIH HHS, Id: DP1 OD000839
  • Agency: NIH HHS, Id: DP1 OD000839-01
  • Agency: NINDS NIH HHS, Id: R01 NS037757
  • Agency: NINDS NIH HHS, Id: R01 NS037757-09

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.