The p53 tumor suppressor gene is mutated in about half of human cancers, but the p53 pathway is thought to be functionally inactivated in the vast majority of cancer. Understanding how tumor cells can become insensitive to p53 activation is therefore of major importance. Using an RNAi-based genetic screen, we have identified three novel genes that regulate p53 function.
Pubmed ID: 19277210 RIS Download
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Cell line U2OS is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line p53HCT116 is a Cancer cell line with a species of origin Homo sapiens (Human)
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