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Fidelity at the molecular level: lessons from protein synthesis.

The faithful and rapid translation of genetic information into peptide sequences is an indispensable property of the ribosome. The mechanistic understanding of strategies used by the ribosome to achieve both speed and fidelity during translation results from nearly a half century of biochemical and structural studies. Emerging from these studies is the common theme that the ribosome uses local as well as remote conformational switches to govern induced-fit mechanisms that ensure accuracy in codon recognition during both tRNA selection and translation termination.

Pubmed ID: 19239893


  • Zaher HS
  • Green R



Publication Data

February 20, 2009

Associated Grants

  • Agency: NIGMS NIH HHS, Id: K99 GM094210
  • Agency: NIGMS NIH HHS, Id: R01 GM059425
  • Agency: Howard Hughes Medical Institute, Id:

Mesh Terms

  • Codon
  • Escherichia coli
  • Protein Biosynthesis
  • RNA, Bacterial
  • RNA, Transfer
  • Ribosomes