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Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking.

The glucocorticoid receptor is a ubiquitous transcription factor mediating adaptation to environmental challenges and stress. Selective Nr3c1 (the glucocorticoid receptor gene) ablation in mouse dopaminoceptive neurons expressing dopamine receptor 1a, but not in dopamine-releasing neurons, markedly decreased the motivation of mice to self-administer cocaine, dopamine cell firing and the control exerted by dopaminoceptive neurons on dopamine cell firing activity. In contrast, anxiety was unaffected, indicating that glucocorticoid receptors modify a number of behavioral disorders through different neuronal populations.

Pubmed ID: 19234455


  • Ambroggi F
  • Turiault M
  • Milet A
  • Deroche-Gamonet V
  • Parnaudeau S
  • Balado E
  • Barik J
  • van der Veen R
  • Maroteaux G
  • Lemberger T
  • Sch├╝tz G
  • Lazar M
  • Marinelli M
  • Piazza PV
  • Tronche F


Nature neuroscience

Publication Data

March 24, 2009

Associated Grants


Mesh Terms

  • Animals
  • Behavior, Addictive
  • Cocaine
  • Cocaine-Related Disorders
  • Dopamine
  • Mice
  • Mice, Transgenic
  • Neurons
  • Receptors, Dopamine D1
  • Receptors, Glucocorticoid
  • Self Administration
  • Stress, Psychological