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A-beta-subtype of ketosis-prone diabetes is not predominantly a monogenic diabetic syndrome.

Diabetes care | 2009

Ketosis-prone diabetes (KPD) is an emerging syndrome that encompasses several distinct phenotypic subgroups that share a predisposition to diabetic ketoacidosis. We investigated whether the A-beta- subgroup of KPD, characterized by complete insulin dependence, absent beta-cell functional reserve, lack of islet cell autoantibodies, and strong family history of type 2 diabetes, represents a monogenic form of diabetes.

Pubmed ID: 19228875 RIS Download

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Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK026190
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL079636
  • Agency: NHGRI NIH HHS, United States
    Id: R21 HG004757

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DTU (tool)

RRID:SCR_008481

It was founded in 1985 by Professor Rury Holman, specialises in performing diabetes-related national and multinational mega trials in partnership with the NHS, NIH, MRC, BHF, DUK, academic institutions and industry. The DTU also undertakes major modelling and statistical programmes to utilise fully the data available from its many studies, with a particular emphasis on modelling diabetes and cardiovascular disease processes. Current studies include 4-T, ACE, TECOS and UKPDS~Post Study Monitoring. Sponsor. Funded by the UK National Institute for Health Research

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