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Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function.

The classical recessive coat color mutation misty (m) arose spontaneously on the DBA/J background and causes generalized hypopigmentation and localized white-spotting in mice, with a lack of pigment on the belly, tail tip, and paws. Here we describe moonlight (mnlt), a second hypopigmentation and white-spotting mutation identified on the C57BL/6J background, which yields a phenotypic copy of m/m coat color traits. We demonstrate that the 2 mutations are allelic. m/m and mnlt/mnlt phenotypes both result from mutations that truncate the dedicator of cytokinesis 7 protein (DOCK7), a widely expressed Rho family guanine nucleotide exchange factor. Although Dock7 is transcribed at high levels in the developing brain and has been implicated in both axon development and myelination by in vitro studies, we find no requirement for DOCK7 in neurobehavioral function in vivo. However, DOCK7 has non-redundant role(s) related to the distribution and function of dermal and follicular melanocytes.

Pubmed ID: 19202056


  • Blasius AL
  • Brandl K
  • Crozat K
  • Xia Y
  • Khovananth K
  • Krebs P
  • Smart NG
  • Zampolli A
  • Ruggeri ZM
  • Beutler BA


Proceedings of the National Academy of Sciences of the United States of America

Publication Data

February 24, 2009

Associated Grants

  • Agency: NIAID NIH HHS, Id: AI070167
  • Agency: NIGMS NIH HHS, Id: GM067759

Mesh Terms

  • Animals
  • Base Sequence
  • Behavior, Animal
  • Female
  • Guanine Nucleotide Exchange Factors
  • Male
  • Mice
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Molecular Sequence Data
  • Mutation
  • Nervous System Physiological Phenomena
  • Pigmentation Disorders