Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice.

http://www.ncbi.nlm.nih.gov/pubmed/19188682

Resistin is an adipokine that contributes to insulin resistance in mice. In humans, however, studies investigating the link between resistin and metabolic disease are conflicting. Further complicating the matter, human resistin is produced mainly by macrophages rather than adipocytes. To address this important issue, we generated mice that lack adipocyte-derived mouse resistin but produce human resistin in a pattern similar to that found in humans, i.e., in macrophages (humanized resistin mice). When placed on a high-fat diet, the humanized resistin mice rapidly developed accelerated white adipose tissue (WAT) inflammation, leading to increased lipolysis and increased serum free fatty acids. Over time, these mice accumulated lipids, including diacylglycerols, in muscle. We found that this resulted in increased Pkcq pathway activity, leading to increased serine phosphorylation of Irs-1 and insulin resistance. Thus, although the site of resistin production differs between species, human resistin exacerbates WAT inflammation and contributes to insulin resistance.

Pubmed ID: 19188682 RIS Download

Mesh terms: Adipose Tissue, White | Animal Structures | Animals | Antigens, CD | Antigens, Differentiation, Myelomonocytic | Blood Glucose | Cell Movement | Cytokines | Dietary Fats | Gene Expression | Glucose Clamp Technique | Glucose Tolerance Test | Humans | Inflammation | Insulin | Insulin Receptor Substrate Proteins | Insulin Resistance | Isoenzymes | Lipid Metabolism | Lipids | Lipolysis | Lipoprotein Lipase | Macrophages | Male | Mice | Mice, Inbred C57BL | Mice, Knockout | Mice, Transgenic | Muscle, Skeletal | Protein Kinase C | Resistin | Restless Legs Syndrome | Signal Transduction

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIDDK NIH HHS, Id: P01 DK49210
  • Agency: British Heart Foundation, Id:

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.