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Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation.

PloS one | 2009

The Phosphatidylinositol 3'-kinase is a key regulator in various cancer-associated signal transduction pathways. Genetic alterations of its catalytic subunit alpha, PIK3CA, have been identified in ovarian cancer. Our in vivo data suggests that PIK3CA activation is one of the early genetic events in ovarian cancer. However, its role in malignant transformation of ovarian surface epithelium (OSE) is largely unclear.

Pubmed ID: 19172191 RIS Download

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: P50 CA083638
  • Agency: NCI NIH HHS, United States
    Id: R01 CA142776
  • Agency: NCI NIH HHS, United States
    Id: P50-CA83638

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B6C3F1 (tool)

RRID:MGI:5649814

Strain Type: Not Specified This is a legacy resource.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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