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Effect of testosterone on insulin stimulated IRS1 Ser phosphorylation in primary rat myotubes--a potential model for PCOS-related insulin resistance.

PloS one | 2009

Polycystic ovary syndrome (PCOS) is characterized by a hyperandrogenic state and frequently develops skeletal muscle insulin resistance. We determined whether testosterone adversely affects insulin action by increasing serine phosphorylation of IRS-1(636/639) in differentiated rat skeletal muscle myotubes. The phosphorylation of Akt, mTOR, and S6K, downstream targets of the PI3-kinase-IRS-1 complex were also studied.

Pubmed ID: 19169352 RIS Download

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Associated grants

  • Agency: NCRR NIH HHS, United States
    Id: KL2 RR024151
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK041973
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK 41973

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SD (tool)

RRID:RGD_70508

Rattus norvegicus with name SD from RGD.

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