• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis.

Blockade of the transient receptor potential channel vanilloid subfamily 1 (TRPV1) is suggested as a therapeutic approach to pain relief. However, TRPV1 is a widely expressed protein whose function might be critical in various nonneuronal physiologic conditions. The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is overexpressed in many human epithelial cancers and is a potential target for anticancer drugs. Here, we show that TRPV1 interacts with EGFR, leading to EGFR degradation. Notably, the absence of TRPV1 in mice results in a striking increase in skin carcinogenesis. The TRPV1 is the first membrane receptor shown to have a tumor-suppressing effect associated with the down-regulation of another membrane receptor. The data suggest that, although a great deal of interest has focused on TRPV1 as a target for pain relief, the chronic blockade of this pain receptor might increase the risk for cancer development.

Pubmed ID: 19155296

Authors

  • Bode AM
  • Cho YY
  • Zheng D
  • Zhu F
  • Ericson ME
  • Ma WY
  • Yao K
  • Dong Z

Journal

Cancer research

Publication Data

February 1, 2009

Associated Grants

  • Agency: NCI NIH HHS, Id: CA007646
  • Agency: NCI NIH HHS, Id: CA027502
  • Agency: NCI NIH HHS, Id: CA088961
  • Agency: NCI NIH HHS, Id: CA111536
  • Agency: NCI NIH HHS, Id: CA120388
  • Agency: NCI NIH HHS, Id: P01 CA027502
  • Agency: NCI NIH HHS, Id: P01 CA027502-270022
  • Agency: NCI NIH HHS, Id: P01 CA088961
  • Agency: NCI NIH HHS, Id: P01 CA088961-020003
  • Agency: NCI NIH HHS, Id: R01 CA077646
  • Agency: NCI NIH HHS, Id: R01 CA077646-09
  • Agency: NCI NIH HHS, Id: R01 CA081064
  • Agency: NCI NIH HHS, Id: R01 CA081064-08
  • Agency: NCI NIH HHS, Id: R01 CA111536
  • Agency: NCI NIH HHS, Id: R01 CA111536-04
  • Agency: NCI NIH HHS, Id: R01 CA120388
  • Agency: NCI NIH HHS, Id: R01 CA120388-03
  • Agency: NCI NIH HHS, Id: R37 CA081064

Mesh Terms

  • Animals
  • Carcinogens
  • Cell Line, Tumor
  • Cell Transformation, Neoplastic
  • Down-Regulation
  • Lysosomes
  • Mice
  • Mice, Knockout
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins c-cbl
  • Receptor, Epidermal Growth Factor
  • Skin Neoplasms
  • TRPV Cation Channels
  • Tetradecanoylphorbol Acetate
  • Ubiquitin