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Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala.

The development of the amygdala, a central structure of the limbic system, remains poorly understood. We found that two spatially distinct and early-specified telencephalic progenitor pools marked by the homeodomain transcription factor Dbx1 are major sources of neuronal cell diversity in the mature mouse amygdala. We found that Dbx1-positive cells of the ventral pallium generate the excitatory neurons of the basolateral complex and cortical amygdala nuclei. Moreover, Dbx1-derived cells comprise a previously unknown migratory stream that emanates from the preoptic area (POA), a ventral telencephalic domain adjacent to the diencephalic border. The Dbx1-positive, POA-derived population migrated specifically to the amygdala and, as defined by both immunochemical and electrophysiological criteria, generated a unique subclass of inhibitory neurons in the medial amygdala nucleus. Thus, this POA-derived population represents a previously unknown progenitor pool dedicated to the limbic system.

Pubmed ID: 19136974


  • Hirata T
  • Li P
  • Lanuza GM
  • Cocas LA
  • Huntsman MM
  • Corbin JG


Nature neuroscience

Publication Data

February 27, 2009

Associated Grants

  • Agency: NIDA NIH HHS, Id: R01 DA020140
  • Agency: NIDA NIH HHS, Id: R01 DA020140-01A1

Mesh Terms

  • Amygdala
  • Animals
  • Cell Movement
  • Female
  • Gene Knock-In Techniques
  • Homeodomain Proteins
  • Integrases
  • Lac Operon
  • Male
  • Membrane Potentials
  • Mice
  • Mice, Mutant Strains
  • Mice, Transgenic
  • Neural Inhibition
  • Neurons
  • Patch-Clamp Techniques
  • Pregnancy
  • Preoptic Area
  • Stem Cell Niche
  • Stem Cells