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Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala.

Nature neuroscience | Feb 27, 2009

The development of the amygdala, a central structure of the limbic system, remains poorly understood. We found that two spatially distinct and early-specified telencephalic progenitor pools marked by the homeodomain transcription factor Dbx1 are major sources of neuronal cell diversity in the mature mouse amygdala. We found that Dbx1-positive cells of the ventral pallium generate the excitatory neurons of the basolateral complex and cortical amygdala nuclei. Moreover, Dbx1-derived cells comprise a previously unknown migratory stream that emanates from the preoptic area (POA), a ventral telencephalic domain adjacent to the diencephalic border. The Dbx1-positive, POA-derived population migrated specifically to the amygdala and, as defined by both immunochemical and electrophysiological criteria, generated a unique subclass of inhibitory neurons in the medial amygdala nucleus. Thus, this POA-derived population represents a previously unknown progenitor pool dedicated to the limbic system.

Pubmed ID: 19136974 RIS Download

Mesh terms: Amygdala | Animals | Cell Movement | Female | Gene Knock-In Techniques | Homeodomain Proteins | Integrases | Lac Operon | Male | Membrane Potentials | Mice | Mice, Mutant Strains | Mice, Transgenic | Neural Inhibition | Neurons | Patch-Clamp Techniques | Pregnancy | Preoptic Area | Stem Cell Niche | Stem Cells

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Associated grants

  • Agency: NIDA NIH HHS, Id: R01 DA020140
  • Agency: NIDA NIH HHS, Id: R01 DA020140-01A1

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