Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala.

Nature neuroscience | Feb 27, 2009

The development of the amygdala, a central structure of the limbic system, remains poorly understood. We found that two spatially distinct and early-specified telencephalic progenitor pools marked by the homeodomain transcription factor Dbx1 are major sources of neuronal cell diversity in the mature mouse amygdala. We found that Dbx1-positive cells of the ventral pallium generate the excitatory neurons of the basolateral complex and cortical amygdala nuclei. Moreover, Dbx1-derived cells comprise a previously unknown migratory stream that emanates from the preoptic area (POA), a ventral telencephalic domain adjacent to the diencephalic border. The Dbx1-positive, POA-derived population migrated specifically to the amygdala and, as defined by both immunochemical and electrophysiological criteria, generated a unique subclass of inhibitory neurons in the medial amygdala nucleus. Thus, this POA-derived population represents a previously unknown progenitor pool dedicated to the limbic system.

Pubmed ID: 19136974 RIS Download

Mesh terms: Amygdala | Animals | Cell Movement | Female | Gene Knock-In Techniques | Homeodomain Proteins | Integrases | Lac Operon | Male | Membrane Potentials | Mice | Mice, Mutant Strains | Mice, Transgenic | Neural Inhibition | Neurons | Patch-Clamp Techniques | Pregnancy | Preoptic Area | Stem Cell Niche | Stem Cells

Research resources used in this publication

None found

Research tools detected in this publication

Data used in this publication

None found

Associated grants

  • Agency: NIDA NIH HHS, Id: R01 DA020140
  • Agency: NIDA NIH HHS, Id: R01 DA020140-01A1

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

Biogen Idec

A global biotechnology company based in Cambridge, Massachusetts, specializing in discovering, developing, and delivering important therapies for the treatment of neurodegenerative, hematologic and autoimmune diseases to patients worldwide. (Wikipedia)


View all literature mentions