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Neuronal release of proBDNF.

Pro-brain-derived neurotrophic factor (proBDNF) and mature BDNF utilize distinct receptors to mediate divergent neuronal actions. Using new tools to quantitate endogenous BDNF isoforms, we found that mouse neurons secrete both proBDNF and mature BDNF. The highest levels of proBDNF and p75 were observed perinatally and declined, but were still detectable, in adulthood. Thus, BDNF actions are developmentally regulated by secretion of proBDNF or mature BDNF and by local expression of p75 and TrkB.

Pubmed ID: 19136973


  • Yang J
  • Siao CJ
  • Nagappan G
  • Marinic T
  • Jing D
  • McGrath K
  • Chen ZY
  • Mark W
  • Tessarollo L
  • Lee FS
  • Lu B
  • Hempstead BL


Nature neuroscience

Publication Data

February 27, 2009

Associated Grants

  • Agency: NINDS NIH HHS, Id: NS30687
  • Agency: NINDS NIH HHS, Id: NS52819
  • Agency: NIMH NIH HHS, Id: P50 MH079513-01A10001
  • Agency: NINDS NIH HHS, Id: R01 NS030687
  • Agency: NINDS NIH HHS, Id: R01 NS030687-17
  • Agency: NINDS NIH HHS, Id: R01 NS052819
  • Agency: NINDS NIH HHS, Id: R01 NS052819-05
  • Agency: Intramural NIH HHS, Id:

Mesh Terms

  • Animals
  • Antibodies, Monoclonal
  • Brain-Derived Neurotrophic Factor
  • Cell Survival
  • Cells, Cultured
  • Gene Expression Regulation, Developmental
  • Gene Knock-In Techniques
  • Hippocampus
  • Mice
  • Mice, Mutant Strains
  • Neurons
  • Protein Precursors
  • Receptor, Nerve Growth Factor
  • Receptor, trkB