Neuronal release of proBDNF.
Pro-brain-derived neurotrophic factor (proBDNF) and mature BDNF utilize distinct receptors to mediate divergent neuronal actions. Using new tools to quantitate endogenous BDNF isoforms, we found that mouse neurons secrete both proBDNF and mature BDNF. The highest levels of proBDNF and p75 were observed perinatally and declined, but were still detectable, in adulthood. Thus, BDNF actions are developmentally regulated by secretion of proBDNF or mature BDNF and by local expression of p75 and TrkB.
Pubmed ID: 19136973 RIS Download
Animals | Antibodies, Monoclonal | Brain-Derived Neurotrophic Factor | Cell Survival | Cells, Cultured | Gene Expression Regulation, Developmental | Gene Knock-In Techniques | Hippocampus | Mice | Mice, Mutant Strains | Neurons | Protein Precursors | Receptor, Nerve Growth Factor | Receptor, trkB