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Early defects in photoreceptor outer segment morphogenesis in zebrafish ift57, ift88 and ift172 Intraflagellar Transport mutants.

Vision research | Feb 24, 2009

Intraflagellar Transport (IFT) refers to a highly conserved process occurring in eukaryotic ciliated structures. In vertebrate photoreceptors, IFT mediates protein trafficking to the outer segments. The IFT particle is a multi-subunit complex and mutations in many individual components causes photoreceptor defects. In zebrafish, mutations in the ift57, ift88, and ift172 genes result in retinal degeneration by 5 days post fertilization (dpf). Although the effects of these mutations on photoreceptor survival have been described, early developmental morphogenesis remains poorly understood. We used transmission electron microscopy and immunohistochemistry to examine these mutants at 60, 72, and 96h post fertilization (hpf) and describe early photoreceptor morphogenesis defects.

Pubmed ID: 19136023 RIS Download

Mesh terms: Adaptor Proteins, Signal Transducing | Animals | Embryo, Nonmammalian | Immunohistochemistry | Microscopy, Electron, Transmission | Morphogenesis | Mutation | Retinal Photoreceptor Cell Outer Segment | Time Factors | Zebrafish | Zebrafish Proteins

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Associated grants

  • Agency: NEI NIH HHS, Id: R01 EY017037
  • Agency: NEI NIH HHS, Id: R01 EY017037-03
  • Agency: NEI NIH HHS, Id: R01EY017037

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