• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Late developmental plasticity in the T helper 17 lineage.

Development of T helper (Th) 17 cells requires transforming growth factor (TGF)-beta and interleukin (IL)-6 and is independent of the Th1 pathway. Although T cells that produce interferon (IFN)-gamma are a recognized feature of Th17 cell responses, mice deficient for STAT4 and T-bet-two prototypical Th1 transcription factors-are protected from autoimmunity associated with Th17 pathogenesis. To examine the fate and pathogenic potential of Th17 cells and origin of IFN-gamma-producing T cells that emerge during Th17 immunity, we developed IL-17F reporter mice that identify cells committed to expression of IL-17F and IL-17A. Th17 cells required TGF-beta for sustained expression of IL-17F and IL-17A. In the absence of TGF-beta, both IL-23 and IL-12 acted to suppress IL-17 and enhance IFN-gamma production in a STAT4- and T-bet-dependent manner, albeit with distinct efficiencies. These results support a model of late Th17 developmental plasticity with implications for autoimmunity and host defense.

Pubmed ID: 19119024

Authors

  • Lee YK
  • Turner H
  • Maynard CL
  • Oliver JR
  • Chen D
  • Elson CO
  • Weaver CT

Journal

Immunity

Publication Data

January 16, 2009

Associated Grants

  • Agency: NIDDK NIH HHS, Id: P01 DK071176
  • Agency: NIDDK NIH HHS, Id: P01 DK071176-01
  • Agency: NIDDK NIH HHS, Id: P01 DK071176-02
  • Agency: NIDDK NIH HHS, Id: P01 DK071176-03
  • Agency: NIDDK NIH HHS, Id: P01 DK071176-04
  • Agency: NIDDK NIH HHS, Id: P01 DK071176-04S1
  • Agency: NIDDK NIH HHS, Id: P01 DK071176-05
  • Agency: NIDDK NIH HHS, Id: P01 DK071176-06
  • Agency: NIDDK NIH HHS, Id: P01 DK071176-07
  • Agency: NIDDK NIH HHS, Id: P01 DK071176-08
  • Agency: NIAID NIH HHS, Id: R01 AI035783
  • Agency: NIAID NIH HHS, Id: R01 AI077574
  • Agency: NIAID NIH HHS, Id: R01 AI077574-01A2
  • Agency: NIAID NIH HHS, Id: R01 AI077574-02
  • Agency: NIAID NIH HHS, Id: R01 AI077574-03
  • Agency: NIAID NIH HHS, Id: R01 AI077574-04
  • Agency: NIDDK NIH HHS, Id: R24 DK064400

Mesh Terms

  • Animals
  • Cell Lineage
  • Cells, Cultured
  • Flow Cytometry
  • Interferon-gamma
  • Interleukin-17
  • Interleukin-23
  • Mice
  • Mice, Knockout
  • T-Lymphocyte Subsets
  • Th1 Cells
  • Th2 Cells
  • Transforming Growth Factor beta