Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Developmentally regulated and evolutionarily conserved expression of SLITRK1 in brain circuits implicated in Tourette syndrome.

Tourette syndrome (TS) is an inherited developmental neuropsychiatric disorder characterized by vocal and motor tics. Multiple lines of neurophysiological evidence implicate dysfunction in the corticostriatal-thalamocortical circuits in the etiology of TS. We recently identified rare sequence variants in the Slit and Trk-like family member 1 (SLITRK1) gene associated with TS. SLITRK1, a single-pass transmembrane protein, displays similarities to the SLIT family of secreted ligands, which have roles in axonal repulsion and dendritic patterning, but its function and developmental expression remain largely unknown. Here we provide evidence that SLITRK1 has a developmentally regulated expression pattern in projection neurons of the corticostriatal-thalamocortical circuits. SLITRK1 is further enriched in the somatodendritic compartment and cytoplasmic vesicles of cortical pyramidal neurons in mouse, monkey, and human brain, observations suggestive of an evolutionarily conserved function in mammals. SLITRK1 is transiently expressed in the striosomal/patch compartment of the mammalian striatum and moreover is associated with the direct output pathway; adult striatal expression is confined to cholinergic interneurons. These analyses demonstrate that the expression of SLITRK1 is dynamic and specifically associated with the circuits most commonly implicated in TS and related disorders, suggesting that SLITRK1 contributes to the development of corticostriatal-thalamocortical circuits.

Pubmed ID: 19105198 RIS Download

Mesh terms: Animals | Brain | Gene Expression Regulation, Developmental | Humans | Immunohistochemistry | Macaca mulatta | Membrane Proteins | Mice | Nerve Tissue Proteins | Neural Pathways | Neurons | Tourette Syndrome

Antibody Registry (Reagent, Antibodies)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.


Monoclonal anti Parvalbumin antibody

parvalbumin human, monkey, rabbit, rat, mouse, chicken, fish

antibody

View all literature mentions

Ctip2 antibody [25B6] - ChIP Grade

Ctip2 antibody [25B6] - ChIP Grade zebrafish/fish, human, mouse, zebrafish

antibody

View all literature mentions

Anti-Choline Acetyltransferase (ChAT) antibody

Choline Acetyltransferase (ChAT) non-human primate, other mammalian, h, r, m, bat, fe, mk

antibody

View all literature mentions

FOXP2 antibody

FOXP2 antibody human, rat, mouse, human, mouse, rat

antibody

View all literature mentions

Rab 11 (H-87) antibody

Rab 11 (H-87) mouse, rat, human, rat, mouse

antibody

View all literature mentions

Rabbit Anti-Giantin Polyclonal Antibody, Unconjugated

Giantin guinea pig, hamster, human, mouse, other, rat, simian, human, monkey, rodent

antibody

View all literature mentions

Rabbit Anti-Rab5 Polyclonal Antibody, Unconjugated

Rab5 - Early Endosome Marker bovine, canine, guinea pig, hamster, human, mouse, rat, simian, reacts with human, mouse, rat, cow, hamster and monkeypredicted to react with dog (100 identity with immunogen) due to sequence homology

antibody

View all literature mentions

Monoclonal Anti-MAP2 antibody produced in mouse

MAP2 antibody produced in mouse chicken/bird, mouse, bovine, human, rat, human, chicken, rat, mouse, quail, bovine

antibody

View all literature mentions

Mouse Anti-Neurofilament H Monoclonal Antibody, Unconjugated, Clone SMI-32

Neurofilament H bovine, canine, donkey, feline, goat, guinea pig, hamster, human, mouse, other, porcine, rabbit, rat, sheep, simian, human, mouse, rat, goat, guinea pig, rabbit, sheep, bovine, canine, donkey, feline, hamster, porcine, simian, other

antibody

View all literature mentions

Methionine Enkephalin Antibody

Methionine Enkephalin See NCBI gene Astyanax Jordani (Fish), Bird, Blowfly, Bovine, Bullfrog, Cat, Chick, Chicken, Cockroach, Cod, Crab, Dog, Fish, Frog, Gerbil, Goldfish, Guinea Pig, Hamster, Human, Lamprey, Leech, Lymnaea Stagnalis (Snail), Manducta Sexta (Moth), Monkey, Mouse, Octopus, Parrot, Pig, Pigeon, Rabbit, Rat, Ratfish, Salamander, Salmon, Sea Bass (Fish), Shrew, Squirrel Monkey, Starling, Tapeworm, Turtle, Zebra Finch (Bird)

antibody

View all literature mentions

Opioid Receptor-Mu (MOR) Antibody

Synthetic rat MOR1 (384-398) Cat, Chicken, Frog, Guinea Pig, Human, Monkey, Mouse, Rat, Starling, Tadpole

antibody

View all literature mentions

Substance P Antibody

Substance P See NCBI gene Bird, Bullfrog, Cat, Chick, Chicken, Dog, Dolphin, Doves, Equine, Fish, Frog, Gerbil, Goat, Goldfish, Guinea Pig, Hamster, Horse, Human, Monkey, Mouse, Mudpuppy, Narwhal, Parrot, Pig, Pig, Pigeon, Quail, Rabbit, Ram (Sheep), Rat, Ratfish, Salmon, Scorpaena Porcus (Fish), Sea Lamprey, Sheep, Snail, Sparus Aurata (Fish), Squalus Acanthias (Dogfish), Squirrel, Starfish, Sting Ray, Sturgeon (Fish), Three-Spined Stickleback (Fish), Trout, Turtle, Vole, Zebra Finch (Bird), Zebrafish

antibody

View all literature mentions