We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish.

We have characterized 28 zebrafish lines with heterozygous mutations in ribosomal protein (rp) genes, and found that 17 of these are prone to develop zebrafish malignant peripheral nerve sheath tumors (zMPNST). Heterozygotes from the vast majority of tumor-prone rp lines were found to be growth-impaired, though not all growth-impaired rp lines were tumor-prone. Significantly, however, the rp lines with the greatest incidence of zMPNSTs all displayed a growth impairment. Furthermore, heterozygous cells from one tumor-prone rp line were out-competed by wild-type cells in chimeric embryos. The growth impairment resulting from heterozygosity for many rp genes suggests that a global defect in protein translation exists in these lines, raising the possibility that a translation defect that precedes tumor development is predictive of tumorigenesis.

Pubmed ID: 19097187 RIS Download

Mesh terms: Animals | Chimera | Disease Susceptibility | Gene Knockdown Techniques | Mutation | Nerve Sheath Neoplasms | Ribosomal Proteins | Zebrafish | Zebrafish Proteins

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

Associated grants

  • Agency: NCI NIH HHS, Id: CA106416
  • Agency: NCI NIH HHS, Id: R01 CA106416-03
  • Agency: NCI NIH HHS, Id: R01 CA106416-04
  • Agency: NCI NIH HHS, Id: R01 CA106416-01A2
  • Agency: NCI NIH HHS, Id: R01 CA106416-02
  • Agency: NCI NIH HHS, Id: R01 CA106416

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.