Our hosting provider will be performing UPS maintenance on Tuesday, Oct 25, 2016 between 8 AM and 5 PM PDT. SciCrunch searching services will be down during this time.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Contribution of hippocampal and extra-hippocampal NR2B-containing NMDA receptors to performance on spatial learning tasks.


Controversy revolves around the differential contribution of NR2A- and NR2B-containing NMDA receptors, which coexist in principal forebrain neurons, to synaptic plasticity and learning in the adult brain. Here, we report genetically modified mice in which the NR2B subunit is selectively ablated in principal neurons of the entire postnatal forebrain or only the hippocampus. NR2B ablation resulted in smaller NMDA receptor-mediated EPSCs with accelerated decay kinetics, as recorded in CA1 pyramidal cells. CA3-to-CA1 field LTP remained largely unaltered, although a pairing protocol revealed decreased NMDA receptor-mediated charge transfer and reduced cellular LTP. Mice lacking NR2B in the forebrain were impaired on a range of memory tasks, presenting both spatial and nonspatial phenotypes. In contrast, hippocampus-specific NR2B ablation spared hippocampus-dependent, hidden-platform water maze performance but induced a selective, short-term, spatial working memory deficit for recently visited places. Thus, both hippocampal and extra-hippocampal NR2B containing NMDA receptors critically contribute to spatial performance.

Pubmed ID: 19081379


  • von Engelhardt J
  • Doganci B
  • Jensen V
  • Hvalby Ø
  • Göngrich C
  • Taylor A
  • Barkus C
  • Sanderson DJ
  • Rawlins JN
  • Seeburg PH
  • Bannerman DM
  • Monyer H



Publication Data

December 10, 2008

Associated Grants

  • Agency: Wellcome Trust, Id: 087736
  • Agency: Wellcome Trust, Id: SRF 074385/Z/04/Z

Mesh Terms

  • Analysis of Variance
  • Animals
  • Behavior, Animal
  • Discrimination (Psychology)
  • Electric Stimulation
  • Electron Transport Complex IV
  • Evoked Potentials
  • Excitatory Amino Acid Agents
  • Excitatory Postsynaptic Potentials
  • Exploratory Behavior
  • Female
  • Hippocampus
  • In Vitro Techniques
  • Male
  • Maze Learning
  • Membrane Potentials
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Mutation
  • Neurons
  • Patch-Clamp Techniques
  • Photic Stimulation
  • Receptors, N-Methyl-D-Aspartate
  • Recognition (Psychology)
  • Space Perception