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Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing.

Nature methods | Jan 31, 2009

http://www.ncbi.nlm.nih.gov/pubmed/19079253

Our variant ascertainment algorithm, VAAL, uses massively parallel DNA sequence data to identify differences between bacterial genomes with high sensitivity and specificity. VAAL detected approximately 98% of differences (including large insertion-deletions) between pairs of strains from three species while calling no false positives. VAAL also pinpointed a single mutation between Vibrio cholerae genomes, identifying an antibiotic's site of action by identifying sequence differences between drug-sensitive strains and drug-resistant derivatives.

Pubmed ID: 19079253 RIS Download

Mesh terms: Algorithms | Base Sequence | DNA, Bacterial | Databases, Nucleic Acid | Polymorphism, Genetic | Sensitivity and Specificity

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