Our hosting provider will be performing UPS maintenance on Tuesday, Oct 25, 2016 between 8 AM and 5 PM PDT. SciCrunch searching services will be down during this time.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma.


Loss of cell polarity proteins such as Scribble induces neoplasia in Drosophila by promoting uncontrolled proliferation. In mammals, the role that polarity proteins play during tumorigenesis is not well understood. Here, we demonstrate that depletion of Scribble in mammary epithelia disrupts cell polarity, blocks three-dimensional morphogenesis, inhibits apoptosis, and induces dysplasia in vivo that progress to tumors after long latency. Loss of Scribble cooperates with oncogenes such as c-myc to transform epithelial cells and induce tumors in vivo by blocking activation of an apoptosis pathway. Like depletion, mislocalization of Scribble from cell-cell junction was sufficient to promote cell transformation. Interestingly, spontaneous mammary tumors in mice and humans possess both downregulated and mislocalized Scribble. Thus, we demonstrate that scribble inhibits breast cancer formation and that deregulation of polarity pathways promotes dysplastic and neoplastic growth in mammals by disrupting morphogenesis and inhibiting cell death.

Pubmed ID: 19041750


  • Zhan L
  • Rosenberg A
  • Bergami KC
  • Yu M
  • Xuan Z
  • Jaffe AB
  • Allred C
  • Muthuswamy SK



Publication Data

November 28, 2008

Associated Grants

  • Agency: NCI NIH HHS, Id: CA098830
  • Agency: NCI NIH HHS, Id: CA105388
  • Agency: NCI NIH HHS, Id: R56 CA098830
  • Agency: NCI NIH HHS, Id: R56 CA098830-05A1

Mesh Terms

  • Animals
  • Apoptosis
  • Breast Neoplasms
  • Cell Line, Tumor
  • Cell Polarity
  • Down-Regulation
  • Epithelial Cells
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Mammary Glands, Animal
  • Mammary Neoplasms, Animal
  • Membrane Proteins
  • Mice
  • Proto-Oncogene Proteins c-myc
  • Tumor Suppressor Proteins