Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis.

Neuron | Nov 26, 2008

http://www.ncbi.nlm.nih.gov/pubmed/19038216

Drugs activating 5-hydroxytryptamine 2C receptors (5-HT2CRs) potently suppress appetite, but the underlying mechanisms for these effects are not fully understood. To tackle this issue, we generated mice with global 5-HT2CR deficiency (2C null) and mice with 5-HT2CRs re-expression only in pro-opiomelanocortin (POMC) neurons (2C/POMC mice). We show that 2C null mice predictably developed hyperphagia, hyperactivity, and obesity and showed attenuated responses to anorexigenic 5-HT drugs. Remarkably, all these deficiencies were normalized in 2C/POMC mice. These results demonstrate that 5-HT2CR expression solely in POMC neurons is sufficient to mediate effects of serotoninergic compounds on food intake. The findings also highlight the physiological relevance of the 5-HT2CR-melanocortin circuitry in the long-term regulation of energy balance.

Pubmed ID: 19038216 RIS Download

Mesh terms: Animals | Appetite | Appetite Depressants | Appetite Regulation | Drug Resistance | Energy Metabolism | Homeostasis | Hyperphagia | Hypothalamus | Mice | Mice, Knockout | Motor Activity | Neural Pathways | Obesity | Pro-Opiomelanocortin | Receptor, Serotonin, 5-HT2C | Serotonin

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: Wellcome Trust, Id: 081713
  • Agency: NIDDK NIH HHS, Id: DK065171
  • Agency: NIDDK NIH HHS, Id: F32 DK63853-01
  • Agency: NIDDK NIH HHS, Id: K08DK068069-01A2
  • Agency: NIDDK NIH HHS, Id: P01 DK56116
  • Agency: NIDDK NIH HHS, Id: R00 DK085330
  • Agency: NIDDK NIH HHS, Id: R01 DK053301
  • Agency: NIMH NIH HHS, Id: R01 MH061583
  • Agency: NIDDK NIH HHS, Id: R01DK53301
  • Agency: NIMH NIH HHS, Id: R01MH61583
  • Agency: NIDDK NIH HHS, Id: RL1 DK081185
  • Agency: NIDDK NIH HHS, Id: RL1DK081185
  • Agency: Wellcome Trust, Id:

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.