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Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR): background commentary of RIVUR investigators.

Because of the frequency of urinary tract infections in children, off-label use of antimicrobial prophylaxis is often the usual treatment of children with vesicoureteral reflux, and such use is increasingly being called into question; hence, a definitive study to determine the value of antimicrobial prophylaxis with regard to the recurrence of urinary tract infection and the incidence of renal scarring is essential. The currently recommended follow-up procedures (repeated urine cultures, renal and genitourinary imaging, antimicrobial therapy and prophylaxis, as well as other factors including cleanliness, adequate bladder and bowel emptying, and compliance with protocols) are expensive (in terms of time, attention to detail, and cost) and cumbersome. Such recommendations should be evidence-based.

Pubmed ID: 19018047


  • Chesney RW
  • Carpenter MA
  • Moxey-Mims M
  • Nyberg L
  • Greenfield SP
  • Hoberman A
  • Keren R
  • Matthews R
  • Matoo TK
  • members of the RIVUR Steering Committee



Publication Data

December 21, 2008

Associated Grants

  • Agency: NIDDK NIH HHS, Id: U01 DK074059
  • Agency: NIDDK NIH HHS, Id: U01 DK074059
  • Agency: NCATS NIH HHS, Id: UL1 TR000005

Mesh Terms

  • Anti-Bacterial Agents
  • Child
  • Child, Preschool
  • Cicatrix
  • Disease Management
  • Double-Blind Method
  • Drug Administration Schedule
  • Early Diagnosis
  • Female
  • Humans
  • Infant
  • Kidney
  • Male
  • Multicenter Studies as Topic
  • Pyelonephritis
  • Randomized Controlled Trials as Topic
  • Recurrence
  • Research Design
  • Unnecessary Procedures
  • Urinary Tract Infections
  • Vesico-Ureteral Reflux