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AutDB: a gene reference resource for autism research.

Nucleic acids research | Jan 16, 2009

Recent advances in studies of Autism Spectrum Disorders (ASD) has uncovered many new candidate genes and continues to do so at an accelerated pace. To address the genetic complexity of ASD, we have developed AutDB (, a publicly available web-portal for on-going collection, manual annotation and visualization of genes linked to the disorder. We present a disease-driven database model in AutDB where all genes connected to ASD are collected and classified according to their genetic variation: candidates identified from genetic association studies, rare single gene mutations and genes linked to syndromic autism. Gene entries are richly annotated for their relevance to autism, along with an in-depth view of their molecular functions. The content of AutDB originates entirely from the published scientific literature and is organized to optimize its use by the research community. The main focus of this resource is to provide an up-to-date, annotated list of ASD candidate genes in the form of reference dataset for interrogating molecular mechanisms underlying the disorder. Our model for consolidated knowledge representation in genetically complex disorders could be replicated to study other such disorders.

Pubmed ID: 19015121 RIS Download

Mesh terms: Autistic Disorder | Databases, Genetic | Genes | Genetic Predisposition to Disease | Genetic Variation | Humans | Reference Standards | Research

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Resource for protein sequence and functional information that welcomes updates, corrections, and the submission of new protein sequence data. It is comprised of four components, each optimized for different uses. UniProt Knowledgebase (UniProtKB) is the central access point for curated protein information, including function, classification, and cross-reference, and contains two sections: UniProtKB/Swiss-Prot, which is manually annotated and reviewed; and UniProtKB/TrEMBL, which is automatically annotated and not reviewed. UniProt Reference Clusters (UniRef) are databases providing clustered sets of sequences from the UniProtKB and selected UniProt Archive records to obtain complete coverage of sequence space at several resolutions while hiding redundant sequences. UniProt Archive (UniParc) is a comprehensive repository used to keep track of sequences and their identifiers. UniProt Metagenomic and Environmental Sequences (UniMES) database is a repository specifically developed for metagenomic and environmental data.


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