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Deficiency of growth differentiation factor 3 protects against diet-induced obesity by selectively acting on white adipose.

Growth differentiation factor 3 (GDF3) is a member of the TGFbeta superfamily. White adipose is one of the tissues in which Gdf3 is expressed, and it is the only tissue in which expression increases in response to high-fat diet. We generated Gdf3-/- mice, which were indistinguishable from wild-type mice and had normal weight curves on regular diet. However, on high-fat diet Gdf3-/- mice were resistant to the obesity that normally develops in wild-type mice. Herein we investigate the physiological and molecular mechanisms that underlie this protection from diet-induced obesity and demonstrate that GDF3 deficiency selectively affects white adipose through its influence on basal metabolic rates. Our results are consistent with a role for GDF3 in adipose tissue, with consequential effects on energy expenditure that ultimately impact adiposity.

Pubmed ID: 19008465


  • Shen JJ
  • Huang L
  • Li L
  • Jorgez C
  • Matzuk MM
  • Brown CW


Molecular endocrinology (Baltimore, Md.)

Publication Data

January 5, 2009

Associated Grants

  • Agency: NIDDK NIH HHS, Id: DK073572
  • Agency: NICHD NIH HHS, Id: HD01156
  • Agency: NICHD NIH HHS, Id: HD27823
  • Agency: NICHD NIH HHS, Id: HD32067
  • Agency: NICHD NIH HHS, Id: HD41648
  • Agency: NIDDK NIH HHS, Id: R01 DK073572
  • Agency: NICHD NIH HHS, Id: R03 HD049138

Mesh Terms

  • 3T3-L1 Cells
  • Adipose Tissue, White
  • Adiposity
  • Animals
  • Basal Metabolism
  • Dietary Fats
  • Energy Metabolism
  • Female
  • Gene Expression
  • Growth Differentiation Factor 3
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Obesity
  • RNA, Messenger