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Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation.

Neural development | 2008

Wnt proteins comprise a large class of signaling molecules that regulate a variety of developmental processes, including synapse formation. Previous studies have shown Wnts to be involved in both the induction and prevention of synapses in a number of different organisms. However, it is not clear whether the influence of Wnts on synapses is a result of Wnts' behavior in different organisms or differences in the activity of different Wnt ligands.

Pubmed ID: 18986540 RIS Download

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Associated grants

  • Agency: NINDS NIH HHS, United States
    Id: R01 NS047484

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