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Genomic-scale prioritization of drug targets: the TDR Targets database.

The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.

Pubmed ID: 18927591


  • Ag├╝ero F
  • Al-Lazikani B
  • Aslett M
  • Berriman M
  • Buckner FS
  • Campbell RK
  • Carmona S
  • Carruthers IM
  • Chan AW
  • Chen F
  • Crowther GJ
  • Doyle MA
  • Hertz-Fowler C
  • Hopkins AL
  • McAllister G
  • Nwaka S
  • Overington JP
  • Pain A
  • Paolini GV
  • Pieper U
  • Ralph SA
  • Riechers A
  • Roos DS
  • Sali A
  • Shanmugam D
  • Suzuki T
  • Van Voorhis WC
  • Verlinde CL


Nature reviews. Drug discovery

Publication Data

November 31, 2008

Associated Grants

  • Agency: NIGMS NIH HHS, Id: R01 GM054762

Mesh Terms

  • Animals
  • Communicable Diseases
  • Databases, Genetic
  • Drug Design
  • Genome
  • Humans