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Human immunodeficiency virus type 1, human protein interaction database at NCBI.

The 'Human Immunodeficiency Virus Type 1 (HIV-1), Human Protein Interaction Database', available through the National Library of Medicine at, was created to catalog all interactions between HIV-1 and human proteins published in the peer-reviewed literature. The database serves the scientific community exploring the discovery of novel HIV vaccine candidates and therapeutic targets. To facilitate this discovery approach, the following information for each HIV-1 human protein interaction is provided and can be retrieved without restriction by web-based downloads and ftp protocols: Reference Sequence (RefSeq) protein accession numbers, Entrez Gene identification numbers, brief descriptions of the interactions, searchable keywords for interactions and PubMed identification numbers (PMIDs) of journal articles describing the interactions. Currently, 2589 unique HIV-1 to human protein interactions and 5135 brief descriptions of the interactions, with a total of 14,312 PMID references to the original articles reporting the interactions, are stored in this growing database. In addition, all protein-protein interactions documented in the database are integrated into Entrez Gene records and listed in the 'HIV-1 protein interactions' section of Entrez Gene reports. The database is also tightly linked to other databases through Entrez Gene, enabling users to search for an abundance of information related to HIV pathogenesis and replication.

Pubmed ID: 18927109


  • Fu W
  • Sanders-Beer BE
  • Katz KS
  • Maglott DR
  • Pruitt KD
  • Ptak RG


Nucleic acids research

Publication Data

January 16, 2009

Associated Grants

  • Agency: NIAID NIH HHS, Id: N01-AI-05415
  • Agency: NIAID NIH HHS, Id: N01-AI-70042
  • Agency: Intramural NIH HHS, Id:

Mesh Terms

  • Acquired Immunodeficiency Syndrome
  • Computer Graphics
  • Databases, Protein
  • HIV-1
  • Humans
  • Protein Interaction Mapping
  • Proteins
  • Viral Proteins
  • gag Gene Products, Human Immunodeficiency Virus