Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

CTLA-4 control over Foxp3+ regulatory T cell function.

Naturally occurring Foxp3+CD4+ regulatory T cells (Tregs) are essential for maintaining immunological self-tolerance and immune homeostasis. Here, we show that a specific deficiency of cytotoxic T lymphocyte antigen 4 (CTLA-4) in Tregs results in spontaneous development of systemic lymphoproliferation, fatal T cell-mediated autoimmune disease, and hyperproduction of immunoglobulin E in mice, and it also produces potent tumor immunity. Treg-specific CTLA-4 deficiency impairs in vivo and in vitro suppressive function of Tregs-in particular, Treg-mediated down-regulation of CD80 and CD86 expression on dendritic cells. Thus, natural Tregs may critically require CTLA-4 to suppress immune responses by affecting the potency of antigen-presenting cells to activate other T cells.

Pubmed ID: 18845758


  • Wing K
  • Onishi Y
  • Prieto-Martin P
  • Yamaguchi T
  • Miyara M
  • Fehervari Z
  • Nomura T
  • Sakaguchi S


Science (New York, N.Y.)

Publication Data

October 10, 2008

Associated Grants


Mesh Terms

  • Animals
  • Antigen-Presenting Cells
  • Antigens, CD
  • Antigens, CD80
  • Antigens, CD86
  • Autoimmune Diseases
  • Autoimmunity
  • CD8-Positive T-Lymphocytes
  • CTLA-4 Antigen
  • Dendritic Cells
  • Down-Regulation
  • Female
  • Forkhead Transcription Factors
  • Immune Tolerance
  • Immunoglobulin E
  • Immunoglobulin G
  • Leukemia
  • Lymphocyte Activation
  • Lymphocytes
  • Male
  • Mice
  • Mice, Inbred BALB C
  • T-Lymphocytes, Regulatory