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Microglia are macrophage-like cells that constantly sense the microenvironment within the central nervous system (CNS). In the event of neuronal stress or injury, microglial cells rapidly react and change their phenotype. This response may lead to a deleterious type of microglial activation, which is often associated with neuroinflammation and neurotoxicity in several neuropathological conditions. We investigated the molecular mechanisms underlying triggering of microglial activation by necrotic neuronal damage.
Pubmed ID: 18844999 RIS Download
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Mus musculus with name C57BL/6J from IMSR.
View all literature mentionsCell line HT22 is a Transformed cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsCell line EL4 is a Cancer cell line with a species of origin Mus musculus (Mouse)
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