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Neuroanatomical abnormalities in adolescents with attention-deficit/hyperactivity disorder.

http://www.ncbi.nlm.nih.gov/pubmed/18827721

OBJECTIVE: Several neuroanatomic abnormalities have been reported in patients with attention-deficit/hyperactivity disorder (ADHD). However, findings are not always consistent, perhaps because of heterogeneous subject samples. Studying youths with documented familial ADHD provides an opportunity to examine a more homogeneous population. METHOD: Twenty-four youths with a confirmed history of familial ADHD and 10 control youths underwent high-resolution structural magnetic resonance imaging examinations. Archived magnetic resonance imaging scan data from 12 control youths were included in the analysis to increase statistical power. Individually drawn region-of-interest methods were used to examine the frontal lobe gyri and caudate. RESULTS: Cerebral total tissue was similar between groups. The volumes of the right caudate and right inferior frontal lobe were larger in the ADHD youths compared with the control youths. Data from a subgroup of the ADHD youths suggest that increasing left caudate volume is associated with decreasing functional activation of this region. CONCLUSIONS: Because previous studies have focused primarily on younger subjects or used an extended age range, the present results may reflect neurodevelopmental changes specific to late adolescence in familial ADHD.

Pubmed ID: 18827721 RIS Download

Mesh terms: Adolescent | Attention Deficit Disorder with Hyperactivity | Caudate Nucleus | Child | Dominance, Cerebral | Female | Follow-Up Studies | Frontal Lobe | Humans | Image Processing, Computer-Assisted | Magnetic Resonance Imaging | Male | Organ Size

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Associated grants

  • Agency: NIMH NIH HHS, Id: K24 MH064478
  • Agency: NIMH NIH HHS, Id: K24 MH064478-01
  • Agency: NIMH NIH HHS, Id: K24 MH064478-02
  • Agency: NIMH NIH HHS, Id: K24 MH064478-03
  • Agency: NIMH NIH HHS, Id: K24 MH064478-04
  • Agency: NIMH NIH HHS, Id: K24 MH064478-05
  • Agency: NIMH NIH HHS, Id: MH064166
  • Agency: NIMH NIH HHS, Id: MH064176
  • Agency: NIMH NIH HHS, Id: MH064177
  • Agency: NIMH NIH HHS, Id: MH064179
  • Agency: NIMH NIH HHS, Id: MH064182
  • Agency: NIDA NIH HHS, Id: N01 DA085548
  • Agency: NIDA NIH HHS, Id: N01 DA085549
  • Agency: NIDA NIH HHS, Id: N01 DA085550
  • Agency: NIDA NIH HHS, Id: N01 DA085551
  • Agency: NIDA NIH HHS, Id: N01 DA085552
  • Agency: NIDA NIH HHS, Id: N01 DA085553
  • Agency: NIDA NIH HHS, Id: N01 DA085554
  • Agency: NIMH NIH HHS, Id: N01 MH012004
  • Agency: NIMH NIH HHS, Id: N01 MH012007
  • Agency: NIMH NIH HHS, Id: N01 MH012008
  • Agency: NIMH NIH HHS, Id: N01 MH012009
  • Agency: NIMH NIH HHS, Id: N01 MH012010
  • Agency: NIMH NIH HHS, Id: N01 MH012011
  • Agency: NIMH NIH HHS, Id: N01 MH012012
  • Agency: NCRR NIH HHS, Id: P41 RR009784
  • Agency: NCRR NIH HHS, Id: P41 RR009784-05
  • Agency: NCRR NIH HHS, Id: P41 RR009784-100125
  • Agency: NIMH NIH HHS, Id: R01 MH064166
  • Agency: NIMH NIH HHS, Id: R01 MH064166-01A1
  • Agency: NIMH NIH HHS, Id: R01 MH064176-01A1
  • Agency: NIMH NIH HHS, Id: R01 MH064177
  • Agency: NIMH NIH HHS, Id: R01 MH064177-01A1
  • Agency: NIMH NIH HHS, Id: R01 MH064179
  • Agency: NIMH NIH HHS, Id: R01 MH064179-01A1
  • Agency: NIMH NIH HHS, Id: R01 MH064179-02
  • Agency: NIMH NIH HHS, Id: R01 MH064182
  • Agency: NIMH NIH HHS, Id: R01 MH064182-01A1
  • Agency: NCRR NIH HHS, Id: RR009784
  • Agency: NIMH NIH HHS, Id: U01 MH050440-08
  • Agency: NIMH NIH HHS, Id: U01 MH050440-08S1
  • Agency: NIMH NIH HHS, Id: U01 MH050447-01
  • Agency: NIMH NIH HHS, Id: U01 MH050453
  • Agency: NIMH NIH HHS, Id: U01 MH050453-08
  • Agency: NIMH NIH HHS, Id: U01 MH050453-08S1
  • Agency: NIMH NIH HHS, Id: U01 MH050454-08
  • Agency: NIMH NIH HHS, Id: U01 MH050454-08S1
  • Agency: NIMH NIH HHS, Id: U01 MH050461
  • Agency: NIMH NIH HHS, Id: U01 MH050461-08
  • Agency: NIMH NIH HHS, Id: U01 MH050467
  • Agency: NIMH NIH HHS, Id: U01 MH050467-08
  • Agency: NIMH NIH HHS, Id: U01 MH050467-08S1

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