Mice lacking the preproenkephalin (ppENK) gene are hyperalgesic and show more anxiety and aggression than wild-type (WT) mice. The marked behavioral changes in ppENK knock-out (KO) mice appeared to occur in supraspinal response to painful stimuli. However the functional role of enkephalins in the supraspinal nociceptive processing and their underlying mechanism is not clear. The aim of present study was to compare supraspinal nociceptive and morphine antinociceptive responses between WT and ppENK KO mice.
Pubmed ID: 18826595 RIS Download
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Mus musculus with name C57BL/6J from IMSR.
View all literature mentionslaboratory mouse with name B6.129-Penk-rstm1Pig from MGI.
View all literature mentionslaboratory mouse with name B6.129-Penk-rstm1Pig from MGI.
View all literature mentions