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White fat progenitor cells reside in the adipose vasculature.

White adipose (fat) tissues regulate metabolism, reproduction, and life span. Adipocytes form throughout life, with the most marked expansion of the lineage occurring during the postnatal period. Adipocytes develop in coordination with the vasculature, but the identity and location of white adipocyte progenitor cells in vivo are unknown. We used genetically marked mice to isolate proliferating and renewing adipogenic progenitors. We found that most adipocytes descend from a pool of these proliferating progenitors that are already committed, either prenatally or early in postnatal life. These progenitors reside in the mural cell compartment of the adipose vasculature, but not in the vasculature of other tissues. Thus, the adipose vasculature appears to function as a progenitor niche and may provide signals for adipocyte development.

Pubmed ID: 18801968

Authors

  • Tang W
  • Zeve D
  • Suh JM
  • Bosnakovski D
  • Kyba M
  • Hammer RE
  • Tallquist MD
  • Graff JM

Journal

Science (New York, N.Y.)

Publication Data

October 24, 2008

Associated Grants

  • Agency: NIDDK NIH HHS, Id: 1R01DK064261
  • Agency: NIDDK NIH HHS, Id: 1R01DK066556
  • Agency: NIDDK NIH HHS, Id: R01 DK064261
  • Agency: NIDDK NIH HHS, Id: R01 DK064261-01
  • Agency: NIDDK NIH HHS, Id: R01 DK064261-02
  • Agency: NIDDK NIH HHS, Id: R01 DK064261-03
  • Agency: NIDDK NIH HHS, Id: R01 DK064261-04
  • Agency: NIDDK NIH HHS, Id: R01 DK064261-05
  • Agency: NIDDK NIH HHS, Id: R01 DK066556
  • Agency: NIDDK NIH HHS, Id: R01 DK066556-01
  • Agency: NIDDK NIH HHS, Id: R01 DK066556-02
  • Agency: NIDDK NIH HHS, Id: R01 DK066556-03
  • Agency: NIDDK NIH HHS, Id: R01 DK066556-04
  • Agency: NIDDK NIH HHS, Id: R01 DK066556-05

Mesh Terms

  • Adipocytes, White
  • Adipogenesis
  • Adipose Tissue
  • Animals
  • Antigens, CD
  • Blood Vessels
  • Cell Lineage
  • Cell Proliferation
  • Cell Separation
  • Cells, Cultured
  • Doxycycline
  • Gene Expression Profiling
  • Mice
  • Mice, Transgenic
  • Multipotent Stem Cells
  • PPAR gamma
  • Stromal Cells