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The Degradome database: mammalian proteases and diseases of proteolysis.

The degradome is defined as the complete set of proteases present in an organism. The recent availability of whole genomic sequences from multiple organisms has led us to predict the contents of the degradomes of several mammalian species. To ensure the fidelity of these predictions, our methods have included manual curation of individual sequences and, when necessary, direct cloning and sequencing experiments. The results of these studies in human, chimpanzee, mouse and rat have been incorporated into the Degradome database, which can be accessed through a web interface at The annotations about each individual protease can be retrieved by browsing catalytic classes and families or by searching specific terms. This web site also provides detailed information about genetic diseases of proteolysis, a growing field of great importance for multiple users. Finally, the user can find additional information about protease structures, protease inhibitors, ancillary domains of proteases and differences between mammalian degradomes.

Pubmed ID: 18776217


  • Quesada V
  • Ordóñez GR
  • Sánchez LM
  • Puente XS
  • López-Otín C


Nucleic acids research

Publication Data

January 16, 2009

Associated Grants


Mesh Terms

  • Animals
  • Databases, Protein
  • Genetic Diseases, Inborn
  • Humans
  • Mice
  • Mutation
  • Pan troglodytes
  • Peptide Hydrolases
  • Proteome
  • Rats