• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo.

NRAGE (also known as Maged1, Dlxin) is a member of the MAGE gene family that may play a role in the neuronal apoptosis that is regulated by the p75 neurotrophin receptor (p75NTR). To test this hypothesis in vivo, we generated NRAGE knockout mice and found that NRAGE deletion caused a defect in developmental apoptosis of sympathetic neurons of the superior cervical ganglia, similar to that observed in p75NTR knockout mice. Primary sympathetic neurons derived from NRAGE knockout mice were resistant to apoptosis induced by brain-derived neurotrophic factor (BDNF), a pro-apoptotic p75NTR ligand, and NRAGE-deficient sympathetic neurons show attenuated BDNF-dependent JNK activation. Hair follicle catagen is an apoptosis-like process that is dependent on p75NTR signaling; we show that NRAGE and p75NTR show regulated co-expression in the hair follicle and that identical defects in hair follicle catagen are present in NRAGE and p75NTR knockout mice. Interestingly, NRAGE knockout mice have severe defects in motoneuron apoptosis that are not observed in p75NTR knockout animals, raising the possibility that NRAGE may facilitate apoptosis induced by receptors other than p75NTR. Together, these studies demonstrate that NRAGE plays an important role in apoptotic-signaling in vivo.

Pubmed ID: 18772898


  • Bertrand MJ
  • Kenchappa RS
  • Andrieu D
  • Leclercq-Smekens M
  • Nguyen HN
  • Carter BD
  • Muscatelli F
  • Barker PA
  • De Backer O


Cell death and differentiation

Publication Data

December 17, 2008

Associated Grants

  • Agency: NINDS NIH HHS, Id: R01 NS038220
  • Agency: NINDS NIH HHS, Id: R01 NS038220-09
  • Agency: NINDS NIH HHS, Id: R01 NS038220-10

Mesh Terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Apoptosis
  • Fertility
  • Gene Targeting
  • Hair Follicle
  • Mice
  • Mice, Knockout
  • Motor Neurons
  • Mutation
  • Neoplasm Proteins
  • Receptor, Nerve Growth Factor
  • Sympathetic Nervous System
  • Trigeminal Ganglion