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The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development.


The extracellular Ca(2+)-sensing receptor (CaSR) plays a nonredundant role in the functions of the parathyroid gland (PTG) and the kidney. Severe hyperparathyroidism, premature death, and incomplete gene excision in Casr(-/-) mice have precluded the assessment of CaSR function in other tissues. We generated mice with tissue-specific deletion of Casr in the PTG, bone, or cartilage. Deletion of Casr in the PTG or bone resulted in profound bone defects, whereas deletion of Casr in chondrocytes (cartilage-producing cells) resulted in death before embryonic day 13 (E13). Mice in which chondrocyte-specific deletion of Casr was induced between E16 and E18 were viable but showed delayed growth plate development. Our data show a critical role for the CaSR in early embryogenesis and skeletal development.

Pubmed ID: 18765830


  • Chang W
  • Tu C
  • Chen TH
  • Bikle D
  • Shoback D


Science signaling

Publication Data

September 3, 2008

Associated Grants

  • Agency: NIAMS NIH HHS, Id: P01-AR39448
  • Agency: NIA NIH HHS, Id: R01 AG021353
  • Agency: NIA NIH HHS, Id: R01 AG021353-08
  • Agency: NIAMS NIH HHS, Id: R01 AR055924
  • Agency: NIDDK NIH HHS, Id: R01 DK054793
  • Agency: NIA NIH HHS, Id: R01-AG21353
  • Agency: NIAMS NIH HHS, Id: R01-AR050023
  • Agency: NIAMS NIH HHS, Id: R21-AR50662

Mesh Terms

  • Animals
  • Bone Development
  • Bone and Bones
  • Calcium Signaling
  • Cartilage
  • Cell Line
  • Chondrocytes
  • Embryo Loss
  • Humans
  • Insulin-Like Growth Factor I
  • Mice
  • Mice, Knockout
  • Osteoblasts
  • Parathyroid Glands
  • Parathyroid Hormone
  • Receptor, IGF Type 1
  • Receptors, Calcium-Sensing