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Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo.

http://www.ncbi.nlm.nih.gov/pubmed/18701545

In Xenopus and zebrafish embryos, elongation of the anterior-posterior body axis depends on convergent extension, a process that involves polarized cell movements and is regulated by non-canonical Wnt signaling. The mechanisms that control axis elongation of the mouse embryo are much less well understood. Here, we characterize the ENU-induced mouse mutation chato, which causes arrest at midgestation and defects characteristic of convergent extension mutants, including a shortened body axis, mediolaterally extended somites and an open neural tube. The chato mutation disrupts Zfp568, a Krüppel-associated box (KRAB) domain zinc-finger protein. Morphometric analysis revealed that the definitive endoderm of mouse wild-type embryos undergoes cell rearrangements that lead to convergent extension during early somite stages, and that these cell rearrangements fail in chato embryos. Although non-canonical Wnt signaling is important for convergent extension in the mouse notochord and neural plate, the results indicate that chato regulates body axis elongation in all embryonic tissues through a process independent of non-canonical Wnt signaling.

Pubmed ID: 18701545 RIS Download

Mesh terms: Alleles | Animals | Body Patterning | Carrier Proteins | Cell Movement | Embryo, Mammalian | Mice | Morphogenesis | Mutation | Nuclear Proteins | Protein Structure, Tertiary | Signal Transduction | Wnt Proteins | Zinc Fingers

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Associated grants

  • Agency: NICHD NIH HHS, Id: HD035455
  • Agency: NICHD NIH HHS, Id: R01 HD035455
  • Agency: NICHD NIH HHS, Id: R01 HD035455-06

Mouse Genome Informatics (Data, Gene Annotation)

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