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Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo.

In Xenopus and zebrafish embryos, elongation of the anterior-posterior body axis depends on convergent extension, a process that involves polarized cell movements and is regulated by non-canonical Wnt signaling. The mechanisms that control axis elongation of the mouse embryo are much less well understood. Here, we characterize the ENU-induced mouse mutation chato, which causes arrest at midgestation and defects characteristic of convergent extension mutants, including a shortened body axis, mediolaterally extended somites and an open neural tube. The chato mutation disrupts Zfp568, a Krüppel-associated box (KRAB) domain zinc-finger protein. Morphometric analysis revealed that the definitive endoderm of mouse wild-type embryos undergoes cell rearrangements that lead to convergent extension during early somite stages, and that these cell rearrangements fail in chato embryos. Although non-canonical Wnt signaling is important for convergent extension in the mouse notochord and neural plate, the results indicate that chato regulates body axis elongation in all embryonic tissues through a process independent of non-canonical Wnt signaling.

Pubmed ID: 18701545


  • García-García MJ
  • Shibata M
  • Anderson KV


Development (Cambridge, England)

Publication Data

September 26, 2008

Associated Grants

  • Agency: NICHD NIH HHS, Id: HD035455
  • Agency: NICHD NIH HHS, Id: R01 HD035455
  • Agency: NICHD NIH HHS, Id: R01 HD035455-06

Mesh Terms

  • Alleles
  • Animals
  • Body Patterning
  • Carrier Proteins
  • Cell Movement
  • Embryo, Mammalian
  • Mice
  • Morphogenesis
  • Mutation
  • Nuclear Proteins
  • Protein Structure, Tertiary
  • Signal Transduction
  • Wnt Proteins
  • Zinc Fingers