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A protein domain-based interactome network for C. elegans early embryogenesis.

Cell | Aug 8, 2008

Many protein-protein interactions are mediated through independently folding modular domains. Proteome-wide efforts to model protein-protein interaction or "interactome" networks have largely ignored this modular organization of proteins. We developed an experimental strategy to efficiently identify interaction domains and generated a domain-based interactome network for proteins involved in C. elegans early-embryonic cell divisions. Minimal interacting regions were identified for over 200 proteins, providing important information on their domain organization. Furthermore, our approach increased the sensitivity of the two-hybrid system, resulting in a more complete interactome network. This interactome modeling strategy revealed insights into C. elegans centrosome function and is applicable to other biological processes in this and other organisms.

Pubmed ID: 18692475 RIS Download

Mesh terms: Animals | Caenorhabditis elegans | Cell Division | Embryo, Nonmammalian | Embryonic Development | Protein Interaction Domains and Motifs | Protein Interaction Mapping | Proteome | Two-Hybrid System Techniques

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Associated grants

  • Agency: NCRR NIH HHS, Id: R21 RR023114-01
  • Agency: NHGRI NIH HHS, Id: R01 HG001715-07
  • Agency: NCI NIH HHS, Id: CA95281
  • Agency: NCI NIH HHS, Id: R21CA113711
  • Agency: NCI NIH HHS, Id: U54 CA112952-03
  • Agency: NCI NIH HHS, Id: R33 CA105405-03
  • Agency: NHGRI NIH HHS, Id: R01 HG001715
  • Agency: NCI NIH HHS, Id: R33CA105405
  • Agency: NHGRI NIH HHS, Id: R01 HG001715-06
  • Agency: NCI NIH HHS, Id: R21 CA113711-01A2
  • Agency: NHGRI NIH HHS, Id: R01 HG001715-10
  • Agency: NCI NIH HHS, Id: U54 CA112952
  • Agency: NHGRI NIH HHS, Id: R01 HG001715-09
  • Agency: NCI NIH HHS, Id: R33 CA105405
  • Agency: NCI NIH HHS, Id: R21 CA113711
  • Agency: NCI NIH HHS, Id: R33 CA105405-01
  • Agency: NCI NIH HHS, Id: R33CA81658
  • Agency: NCI NIH HHS, Id: R33 CA105405-02
  • Agency: NHGRI NIH HHS, Id: R01HG001715
  • Agency: NCI NIH HHS, Id: R33 CA081658-04
  • Agency: NCRR NIH HHS, Id: R21RR023114
  • Agency: NCI NIH HHS, Id: P01 CA095281-01A10004
  • Agency: NCI NIH HHS, Id: U54 CA011295
  • Agency: NCI NIH HHS, Id: P01 CA095281
  • Agency: NCI NIH HHS, Id: U54 CA112952-01
  • Agency: NHGRI NIH HHS, Id: R01 HG001715-07S1
  • Agency: NHGRI NIH HHS, Id: R01 HG001715-08
  • Agency: NCI NIH HHS, Id: U54 CA112952-02
  • Agency: NCRR NIH HHS, Id: R21 RR023114-02
  • Agency: NCRR NIH HHS, Id: R21 RR023114
  • Agency: NCI NIH HHS, Id: R33 CA081658

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