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Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms.

Toll-like receptors (TLRs) play prominent roles in initiating immune responses to infection, but their roles in particular cell types in vivo are not established. Here we report the generation of mice selectively lacking the crucial TLR-signaling adaptor MyD88 in dendritic cells (DCs). In these mice, the early production of inflammatory cytokines, especially IL-12, was substantially reduced after TLR stimulation. Whereas the innate interferon-gamma response of natural killer cells and of natural killer T cells and the Th1 polarization of antigen-specific CD4(+) T cells were severely compromised after treatment with a soluble TLR9 ligand, they were largely intact after administration of an aggregated TLR9 ligand. These results demonstrate that the physical form of a TLR ligand affects which cells can respond to it and that DCs and other innate immune cells can respond via TLRs and collaborate in promoting Th1 adaptive immune responses to an aggregated stimulus.

Pubmed ID: 18656388

Authors

  • Hou B
  • Reizis B
  • DeFranco AL

Journal

Immunity

Publication Data

August 15, 2008

Associated Grants

  • Agency: NIAID NIH HHS, Id: AI067804
  • Agency: NIAID NIH HHS, Id: R01 AI072058
  • Agency: NIAID NIH HHS, Id: R01 AI072058
  • Agency: NIAID NIH HHS, Id: R01 AI072058-01A1

Mesh Terms

  • Animals
  • CD4-Positive T-Lymphocytes
  • Dendritic Cells
  • Fatty Acids, Monounsaturated
  • Immunity, Active
  • Immunity, Innate
  • Immunoglobulin Class Switching
  • Interferon-gamma
  • Interleukin-12
  • Killer Cells, Natural
  • Mice
  • Mice, Knockout
  • Myeloid Differentiation Factor 88
  • Oligodeoxyribonucleotides
  • Quaternary Ammonium Compounds
  • Recombination, Genetic
  • Th1 Cells
  • Toll-Like Receptors