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Type III neuregulin-1 is required for normal sensorimotor gating, memory-related behaviors, and corticostriatal circuit components.

Neuregulin-1 (Nrg1)/erbB signaling regulates neuronal development, migration, myelination, and synaptic maintenance. The Nrg1 gene is a schizophrenia susceptibility gene. To understand the contribution of Nrg1 signaling to adult brain structure and behaviors, we studied the regulation of type III Nrg1 expression and evaluated the effect of decreased expression of the type III Nrg1 isoforms. Type III Nrg1 is transcribed by a promoter distinct from those for other Nrg1 isoforms and, in the adult brain, is expressed in the medial prefrontal cortex, ventral hippocampus, and ventral subiculum, regions involved in the regulation of sensorimotor gating and short-term memory. Adult heterozygous mutant mice with a targeted disruption for type III Nrg1 (Nrg1(tm1.1Lwr+/-)) have enlarged lateral ventricles and decreased dendritic spine density on subicular pyramidal neurons. Magnetic resonance imaging of type III Nrg1 heterozygous mice revealed hypofunction in the medial prefrontal cortex and the hippocampal CA1 and subiculum regions. Type III Nrg1 heterozygous mice also have impaired performance on delayed alternation memory tasks, and deficits in prepulse inhibition (PPI). Chronic nicotine treatment eliminated differences in PPI between type III Nrg1 heterozygous mice and their wild-type littermates. Our findings demonstrate a role of type III Nrg1 signaling in the maintenance of corticostriatal components and in the neural circuits involved in sensorimotor gating and short-term memory.

Pubmed ID: 18596162


  • Chen YJ
  • Johnson MA
  • Lieberman MD
  • Goodchild RE
  • Schobel S
  • Lewandowski N
  • Rosoklija G
  • Liu RC
  • Gingrich JA
  • Small S
  • Moore H
  • Dwork AJ
  • Talmage DA
  • Role LW


The Journal of neuroscience : the official journal of the Society for Neuroscience

Publication Data

July 2, 2008

Associated Grants

  • Agency: NIDA NIH HHS, Id: DA019941
  • Agency: NIMH NIH HHS, Id: L30 MH075110
  • Agency: NINDS NIH HHS, Id: NS29071
  • Agency: NIMH NIH HHS, Id: P50 MH066171
  • Agency: NIMH NIH HHS, Id: P50 MH66171-01
  • Agency: NIMH NIH HHS, Id: R01 MH064168
  • Agency: NINDS NIH HHS, Id: R01 NS029071
  • Agency: NINDS NIH HHS, Id: R01 NS029071-17
  • Agency: NINDS NIH HHS, Id: R01 NS029071-18
  • Agency: NIDA NIH HHS, Id: R21 DA019941
  • Agency: NIDA NIH HHS, Id: R21 DA019941-02

Mesh Terms

  • Animals
  • Atrophy
  • Corpus Striatum
  • Disease Models, Animal
  • Gene Expression Regulation, Developmental
  • Heterozygote
  • Hippocampus
  • Lateral Ventricles
  • Memory Disorders
  • Memory, Short-Term
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Nerve Tissue Proteins
  • Nervous System Malformations
  • Neural Inhibition
  • Neural Pathways
  • Neuregulin-1
  • Nicotinic Agonists
  • Prefrontal Cortex
  • Promoter Regions, Genetic
  • Protein Isoforms
  • Sensation Disorders