• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Striatal activity underlies novelty-based choice in humans.

The desire to seek new and unfamiliar experiences is a fundamental behavioral tendency in humans and other species. In economic decision making, novelty seeking is often rational, insofar as uncertain options may prove valuable and advantageous in the long run. Here, we show that, even when the degree of perceptual familiarity of an option is unrelated to choice outcome, novelty nevertheless drives choice behavior. Using functional magnetic resonance imaging (fMRI), we show that this behavior is specifically associated with striatal activity, in a manner consistent with computational accounts of decision making under uncertainty. Furthermore, this activity predicts interindividual differences in susceptibility to novelty. These data indicate that the brain uses perceptual novelty to approximate choice uncertainty in decision making, which in certain contexts gives rise to a newly identified and quantifiable source of human irrationality.

Pubmed ID: 18579085

Authors

  • Wittmann BC
  • Daw ND
  • Seymour B
  • Dolan RJ

Journal

Neuron

Publication Data

June 26, 2008

Associated Grants

  • Agency: Wellcome Trust, Id:

Mesh Terms

  • Adult
  • Brain Mapping
  • Choice Behavior
  • Corpus Striatum
  • Exploratory Behavior
  • Female
  • Humans
  • Male
  • Photic Stimulation
  • Psychomotor Performance