The determination of left/right body axis during early embryogenesis sets up a developmental cascade that coordinates the development of the viscera and is essential to the correct placement and alignment of organ systems and vasculature. Defective left-right patterning can lead to congenital cardiac malformations, vascular anomalies and other serious health problems. Here we describe a novel role for the T-box transcription factor gene Tbx6 in left/right body axis determination in the mouse.
Pubmed ID: 18575602 RIS Download
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A commercial software package that works with Carl Zeiss microscopy; AIM 4.2 software.
View all literature mentionsMus musculus with name B6.L-Tbx6rv/J from IMSR.
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