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Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling.

PloS one | 2008

The determination of left/right body axis during early embryogenesis sets up a developmental cascade that coordinates the development of the viscera and is essential to the correct placement and alignment of organ systems and vasculature. Defective left-right patterning can lead to congenital cardiac malformations, vascular anomalies and other serious health problems. Here we describe a novel role for the T-box transcription factor gene Tbx6 in left/right body axis determination in the mouse.

Pubmed ID: 18575602 RIS Download

Research resources used in this publication

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Antibodies used in this publication

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Associated grants

  • Agency: NICHD NIH HHS, United States
    Id: HD033082
  • Agency: NICHD NIH HHS, United States
    Id: HD052115
  • Agency: NIGMS NIH HHS, United States
    Id: R01 GM060561
  • Agency: NIGMS NIH HHS, United States
    Id: GM60561
  • Agency: NICHD NIH HHS, United States
    Id: R01 HD033082
  • Agency: NICHD NIH HHS, United States
    Id: R37 HD033082
  • Agency: NICHD NIH HHS, United States
    Id: R01 HD052115

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This is a list of tools and resources that we have found mentioned in this publication.


Zeiss AIM 4.2 SP1 software (tool)

RRID:SCR_015695

A commercial software package that works with Carl Zeiss microscopy; AIM 4.2 software.

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B6.L-Tbx6rv/J (tool)

RRID:IMSR_JAX:001052

Mus musculus with name B6.L-Tbx6rv/J from IMSR.

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