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Bitter taste receptor gene polymorphisms are an important factor in the development of nicotine dependence in African Americans.

CONTEXT: Bitter sensitivity varies among individuals and ethnic groups partly due to polymorphisms in taste receptor genes (TAS2Rs). Although previous psychophysical studies suggest that taste status plays a role in nicotine dependence (ND), genetic evidence is lacking. OBJECTIVES: To determine whether single nucleotide polymorphisms (SNPs) in TAS2R16 and TAS2R38 are associated with ND and if the effects differ by sex and ethnicity. DESIGN, SETTING, AND PARTICIPANTS: 2037 individuals from 602 nuclear families of African American (AA) or European American (EA) origin were recruited from the US mid-south states during 1999-2004. MAIN OUTCOME MEASURES: ND was assessed by three measures: indexed Smoking Quantity (SQ), Heaviness of Smoking Index (HSI), and the Fagerström Test for Nicotine Dependence (FTND). Peripheral blood samples were obtained for DNA extraction and genotyping. RESULTS: The TAS2R38 taster haplotype PAV was inversely associated (p = 0.0165), and the non-taster haplotype AVI was positively associated (p = 0.0120), with SQ in AA smokers. The non-taster haplotype was positively associated with all ND measures in AA female smokers (p = 0.01 approximately 0.003). No significant associations were observed in the EA sample. CONCLUSIONS: TAS2R38 polymorphisms are an important factor in determining ND in AAs. Heightened oral sensitivity confers protection against ND. Conversely, decreased sensitivity represents a risk factor for ND, especially in AA females. Together, our findings suggest that taster status plays a role in governing the development of ND and may represent a way to identify individuals at risk for developing ND, particularly in AA smokers.

Pubmed ID: 18524836

Authors

  • Mangold JE
  • Payne TJ
  • Ma JZ
  • Chen G
  • Li MD

Journal

Journal of medical genetics

Publication Data

September 2, 2008

Associated Grants

  • Agency: NIDA NIH HHS, Id: R01-DA12844

Mesh Terms

  • Adult
  • African Americans
  • Female
  • Haplotypes
  • Humans
  • Male
  • Polymorphism, Single Nucleotide
  • Receptors, G-Protein-Coupled
  • Sex Factors
  • Tobacco Use Disorder